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Small CRISPR RNAs guide antiviral defense in prokaryotes.

Abstract:

Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats (CRISPRs). Here we show how virus-derived sequences contained in CRISPRs are used by CRISPR-associated (Cas) proteins from the host to mediate an antiviral response that counteracts infection. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage pr...

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Publisher copy:
10.1126/science.1159689

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Journal:
Science (New York, N.Y.) More from this journal
Volume:
321
Issue:
5891
Pages:
960-964
Publication date:
2008-08-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075

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