Journal article icon

Journal article

T cell responses are governed by avidity and co-stimulatory thresholds.

Abstract:

We analyzed the avidity and CD28-mediated co-stimulatory requirements for the activation of T cells in vivo and in vitro. The strength of the T cell/antigen-presenting cell interaction was varied by using altered peptide ligands for stimulation. Co-stimulatory requirements were studied using T cells from CD28-deficient mice. The results indicate that T cell activation is not an all-or-nothing event, but occurs in distinct steps. For each step, a certain avidity, co-stimulatory threshold or bo...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/eji.1830260908

Authors


Bachmann, MF More by this author
Kündig, TM More by this author
Shahinian, A More by this author
Speiser, DE More by this author
Expand authors...
Journal:
European journal of immunology
Volume:
26
Issue:
9
Pages:
2017-2022
Publication date:
1996-09-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:f52d4710-a0e1-4b77-99ce-6613444eb101
Source identifiers:
469258
Local pid:
pubs:469258

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP