- Abstract:
-
X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing. The mechanisms by which Xist RNA binds and spreads along the chromosome, and initiates Xist-mediated chromosome silencing remain poorly underst...
Expand abstract - Publisher copy:
- 10.1007/s00439-011-1027-4
-
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- Journal:
- Human Genetics
- Volume:
- 130
- Issue:
- 2
- Pages:
- 247-253
- Publication date:
- 2011-08-05
- DOI:
- EISSN:
-
1432-1203
- ISSN:
-
0340-6717
- URN:
-
uuid:f52894f5-5e9d-4b18-a5a5-79d258562a4f
- Source identifiers:
-
172497
- Local pid:
- pubs:172497
- Language:
- English
- Copyright date:
- 2011
Journal article
A scaffold for X chromosome inactivation
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