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A scaffold for X chromosome inactivation

Abstract:

X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing. The mechanisms by which Xist RNA binds and spreads along the chromosome, and initiates Xist-mediated chromosome silencing remain poorly underst...

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Publisher copy:
10.1007/s00439-011-1027-4

Authors


Tattermusch, A More by this author
Brockdorff, N More by this author
Journal:
Human Genetics
Volume:
130
Issue:
2
Pages:
247-253
Publication date:
2011-08-05
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
URN:
uuid:f52894f5-5e9d-4b18-a5a5-79d258562a4f
Source identifiers:
172497
Local pid:
pubs:172497
Language:
English

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