Journal article : Review
Models of the cardiac L-type calcium current: a quantitative review
- Abstract:
- The L-type calcium current (ICaL) plays a critical role in cardiac electrophysiology, and models of ICaL are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modeling ICaL have resulted in several competing theories (encoded in mathematical equations). However, the introduction of new models has not typically been accompanied by a data-driven critical comparison with previous work, so that it is unclear which model is best suited for any particular application. In this review, we describe and compare 73 published mammalian ICaL models and use simulated experiments to show that there is a large variability in their predictions, which is not substantially diminished when grouping by species or other categories. We provide model code for 60 models, list major data sources, and discuss experimental and modeling work that will be required to reduce this huge list of competing theories and ultimately develop a community consensus model of ICaL.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 10.6MB, Terms of use)
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- Publisher copy:
- 10.1002/wsbm.1581
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 212203/Z/18/Z
+ UK Engineering and Physical Sciences Research Council
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- Grant:
- EP/S024093/1
- EP/L016044/1
- Publisher:
- Wiley
- Journal:
- WIREs Mechanisms of Disease More from this journal
- Volume:
- 15
- Issue:
- 1
- Article number:
- e1581
- Place of publication:
- United States
- Publication date:
- 2022-08-26
- Acceptance date:
- 2022-07-19
- DOI:
- EISSN:
-
2692-9368
- Pmid:
-
36028219
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
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1277241
- Local pid:
-
pubs:1277241
- Deposit date:
-
2023-05-23
- ARK identifier:
Terms of use
- Copyright holder:
- Agrawal et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. WIREs Mechanisms of Disease published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Notes:
- This work is related to the thesis The cardiac L-type calcium current: existing models and methods of improvement.
- Licence:
- CC Attribution (CC BY)
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