Journal article

Hypoxia-driven elimination of thiopurines from their nitrobenzyl prodrugs.

Abstract:: A novel bioreductive prodrug of 6-thioguanine, 2-amino-6-[2-(4-nitrophenyl)prop-2-ylsulfanyl]-9H-purine, containing a gem-dimethyl thioether linkage, was synthesised and compared with its unsubstituted analogue. In A549 whole cell experiments hypoxia selective release of 6-thioguanine was observed with the substituted prodrug only.

Publication status:: Published

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APA Style

Thomson, P., Naylor, M., Stratford, M. R., Lewis, G., Hill, S., Patel, K., Wardman, P., & Davis, P. (2007). Hypoxia-driven elimination of thiopurines from their nitrobenzyl prodrugs. Bioorganic and Medicinal Chemistry Letters, 17(15), 4320–4322.

MLA Style

Thomson, P, et al. “Hypoxia-Driven Elimination of Thiopurines from Their Nitrobenzyl Prodrugs.” Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 15, 2007, pp. 4320–22.

Chicago Style

Thomson, P, M Naylor, MR Stratford, et al. 2007. “Hypoxia-Driven Elimination of Thiopurines from Their Nitrobenzyl Prodrugs.” Bioorganic and Medicinal Chemistry Letters 17 (15): 4320–22.
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Publisher copy:: 10.1016/j.bmcl.2007.05.018

Authors

+ Thomson, P More by this author

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+ Naylor, M More by this author

Role:: Author

+ Stratford, MR More by this author

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+ Lewis, G More by this author

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+ Hill, S More by this author

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Journal:: Bioorganic and medicinal chemistry letters More from this journal
Volume:: 17
Issue:: 15
Pages:: 4320-4322
Publication date:: 2007-08-01
DOI:: 10.1016/j.bmcl.2007.05.018
EISSN:: 1464-3405
ISSN:: 0960-894X

Language:: English
Keywords:: Prodrugs

Humans

Purines

Cell Line

Mass Spectrometry

Cell Hypoxia

Magnetic Resonance Spectroscopy
Pubs id:: pubs:131964
UUID:: uuid:f523536c-be37-417d-b3b5-dc57466b7175
Local pid:: pubs:131964
Source identifiers:: 131964
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_f523536cbe37417db3b5dc57466b7175

Terms of use

Copyright date:: 2007

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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