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Journal article

Passive tumour targeting of polymer-coated adenovirus for cancer gene therapy.

Abstract:

Adenovirus provides many opportunities as a vector for delivery of cytotoxic genes to tumours. Polymer coating of adenovirus is known to increase its plasma circulation kinetics, affording the possibility of active and passive targeting to tumours. Here we show that polymer-coating adenovirus (pc-virus) abrogates its normal infectivity in vitro and also in liver following intravenous injection. The coated virus accumulates within solid subcutaneous AB22 mesothelioma tumours 40-times more than...

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Publication status:
Published

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Publisher copy:
10.1080/10611860701501014

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Journal:
Journal of drug targeting More from this journal
Volume:
15
Issue:
7-8
Pages:
546-551
Publication date:
2007-01-01
DOI:
EISSN:
1029-2330
ISSN:
1061-186X
Language:
English
Keywords:
Pubs id:
pubs:178549
UUID:
uuid:f51b21c4-2c91-459b-81c4-3266998246bc
Local pid:
pubs:178549
Source identifiers:
178549
Deposit date:
2012-12-19

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