Simulation studies on bacteriorhodopsin bundle of transmembrane alpha segments.

Journal article

Bacteriorhodopsin (BR) is a membrane protein which pumps protons through the plasma membrane. Seven transmembrane BR helical segments are subjected to simulation studies in order to investigate the packing process of transmembrane helices. A Monte Carlo simulated annealing protocol is employed to optimize the helix bundle system. Helix packing is optimized according to a semi-empirical potential mainly composed of six components: a bilayer potential, a crossing angle potential, a helix dipole...

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Authors: Son, H; Kerr, I; Sansom, MS

• Publication status: Published
• Journal: European biophysics journal : EBJ
• Volume: 28
• Issue: 8
• Pages: 663-673
• Publication date: 2000-01-01
• DOI: 10.1007/s002490050006
• EISSN: 1432-1017
• ISSN: 0175-7571
• Language: English
• Keywords: Bacteriorhodopsins; Models, Molecular; Protein Structure, Secondary; Amino Acid Sequence; Molecular Sequence Data; Peptide Fragments; Computer Simulation; Monte Carlo Method