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Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.

Abstract:

Osteoblasts undergo apoptosis both in vitro and in vivo in response to high dose glucocorticoid (GC) treatment. However, the molecular mechanisms remain elusive, hindering the prevention and treatment of this side-effect. Apoptosis was induced by dexamethasone (Dex) in murine MBA-15.4 osteoblasts within 24-48 h of treatment. We found dose- and time-dependent upregulation of Bim protein, a pro-apoptotic Bcl-2 family member, with highest levels at 24-48 h for 1 microM Dex. This was also observe...

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Publication status:
Published

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Publisher copy:
10.1002/jcp.21335

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of cellular physiology
Volume:
215
Issue:
2
Pages:
488-496
Publication date:
2008-05-05
DOI:
EISSN:
1097-4652
ISSN:
0021-9541
URN:
uuid:f514e787-b5f6-4bd8-b284-b4df35a35436
Source identifiers:
107531
Local pid:
pubs:107531

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