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Journal article

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis.

Abstract:

Oxidative stress and inflammation--two components of the natural host response to injury--constitute important etiologic factors in atherogenesis. The pro-inflammatory cytokine interleukin (IL)-1 significantly enhances atherosclerosis, however, the molecular mechanisms of IL-1 induction within the artery wall remain poorly understood. Here we have identified the oxidative stress-responsive transcription factor NF-E2-related 2 (Nrf2) as an essential positive regulator of inflammasome activatio...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201190044

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Journal:
European journal of immunology
Volume:
41
Issue:
7
Pages:
2040-2051
Publication date:
2011-07-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:f510e926-c452-462c-8cd7-c7888255f6eb
Source identifiers:
422309
Local pid:
pubs:422309

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