Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis.

Journal article

Oxidative stress and inflammation--two components of the natural host response to injury--constitute important etiologic factors in atherogenesis. The pro-inflammatory cytokine interleukin (IL)-1 significantly enhances atherosclerosis, however, the molecular mechanisms of IL-1 induction within the artery wall remain poorly understood. Here we have identified the oxidative stress-responsive transcription factor NF-E2-related 2 (Nrf2) as an essential positive regulator of inflammasome activatio...

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Authors: Freigang, S; Ampenberger, F; Spohn, G; Heer, S; Shamshiev, A

• Publication status: Published
• Journal: European journal of immunology
• Volume: 41
• Issue: 7
• Pages: 2040-2051
• Publication date: 2011-07-01
• DOI: 10.1002/eji.201190044
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Signal Transduction; Plaque, Atherosclerotic; Interleukin-1; Foam Cells; Mice; Atherosclerosis; Caspase 1; Cholesterol; Apolipoproteins E; Macrophages; Carrier Proteins; Crystallization; Cells, Cultured; Inflammasomes; Dendritic Cells; Oxidative Stress; Mice, Inbred C57BL; NF-E2-Related Factor 2; Mice, Knockout; Animals