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Journal article

Genomic instability--the engine of tumorigenesis?

Abstract:

Human cancers harbour numerous mutations and it has been proposed that these result from some form of inherent genomic instability. Some cancers have proven genomic instability or features that are indicative of this. Inherited cancer syndromes exist that are caused by deficient DNA repair or chromosomal integrity. By contrast, theoretical analysis and experimental data from sporadic colorectal tumours provide little general evidence of genomic instability in early lesions. These apparently c...

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Publisher copy:
10.1038/nrc1170

Authors


Journal:
Nature reviews. Cancer
Volume:
3
Issue:
9
Pages:
701-708
Publication date:
2003-09-05
DOI:
EISSN:
1474-1768
ISSN:
1474-175X
URN:
uuid:f50f4b9c-e4e2-4e9b-b9a8-afcbcb392ffa
Source identifiers:
72217
Local pid:
pubs:72217

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