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Functionalization of mesoporous silica nanoparticles with a cell-penetrating peptide to target mammalian sperm in vitro.

Abstract:

This study aimed to investigate the effects of actively targeting mesoporous silica nanoparticles (MSNPs) toward mammalian sperm with a cell-penetrating peptide (C105Y), with subsequent analysis of binding rates and nano-safety profiles.Boar sperm were exposed in vitro to C105Y-functionalized MSNPs or free C105Y, in a series of increasing doses for up to 2 h, followed by the evaluation of sperm motility, kinematic parameters, acrosome morphology, MSNP-sperm binding and cell fluorescence level...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2217/nnm.14.235

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
Publisher:
Future Medicine
Journal:
Nanomedicine (London, England) More from this journal
Volume:
10
Issue:
10
Pages:
1539-1553
Publication date:
2015-05-01
DOI:
EISSN:
1748-6963
ISSN:
1743-5889
Language:
English
Keywords:
Pubs id:
pubs:524821
UUID:
uuid:f50c38e4-c1ae-4492-b86e-b0a5e9357a12
Local pid:
pubs:524821
Source identifiers:
524821
Deposit date:
2015-12-26

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