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Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors.

Abstract:

Membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14) is an enzyme that promotes tumor cell invasion in tissues. Although the proteolytic activity of MT1-MMP is indispensable for invasion, it is also regulated by functions of the cytoplasmic tail. In this study we obtained a new human gene whose product binds to the tail sequence in yeast. The product, MTCBP-1, is a 19-kDa protein that belongs to the newly proposed Cupin superfamily composed of proteins with diverse functions. MTCBP-1 exp...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m309957200

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
279
Issue:
13
Pages:
12734-12743
Publication date:
2004-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:f50205ef-a2d5-4c01-b835-ce13c5733220
Source identifiers:
224092
Local pid:
pubs:224092

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