Journal article icon

Journal article

Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide.

Abstract:

The major histocompatibility complex class I molecule HLA-A2.1 presents the influenza A virus matrix peptide 57-68 to cytotoxic T lymphocytes in all individuals with this common HLA type and is among the most thoroughly studied immune responses in humans. We have studied the T-cell receptor (TCR) heterogeneity of T cells specific for HLA-A2 and influenza A matrix peptide using the polymerase chain reaction. The usage of V alpha and V beta sequences seen on these T cells is remarkably conserve...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.88.20.8987

Authors


Rosenberg, WM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Target Discovery Institute
Bodmer, HC More by this author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
88
Issue:
20
Pages:
8987-8990
Publication date:
1991-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f4fc725f-caa0-496a-b2ee-9af8d32c81af
Source identifiers:
34170
Local pid:
pubs:34170

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP