Asymmetric droplet interface bilayers.

Journal article

In cell membranes, the lipid compositions of the inner and outer leaflets differ. Therefore, a robust model system that enables single-channel electrical recording with asymmetric bilayers would be very useful. We and others recently developed the droplet interface bilayer (DIB), which is formed by connecting lipid monolayer-encased aqueous droplets submerged in an oil-lipid mixture. Here, we incorporate lipid vesicles of different compositions into aqueous droplets and immerse them in an oil...

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Authors: Hwang, W; Chen, M; Cronin, B; Holden, M; Bayley, H

• Publication status: Published
• Journal: Journal of the American Chemical Society
• Volume: 130
• Issue: 18
• Pages: 5878-5879
• Publication date: 2008-05-01
• DOI: 10.1021/ja802089s
• EISSN: 1520-5126
• ISSN: 0002-7863
• Language: English
• Keywords: Lipids; Alkanes; Membrane Proteins; Ion Channels; Water; Solutions; Bacterial Outer Membrane Proteins; Porins; Escherichia coli Proteins; Lipid Bilayers