Journal article
Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity
- Abstract:
- An efficient approach for the introduction of 3-acyl side chain groups onto a core tetramate system, which are suitable for further manipulation by nucleophilic displacement or Horner-Wadsworth-Emmons coupling, provides access to a diverse library of substituted tetramates related to two distinct classes of natural products, equisetin and pramanicin. Assessment against S. aureus and E. coli indicated that some compounds exhibit significant antibacterial activity, providing unusual leads for further optimisation in the drug discovery process.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 396.5KB, Terms of use)
-
- Publisher copy:
- 10.1039/c4ob00095a
Authors
- Publisher:
- Royal Society of Chemistry
- Journal:
- Organic and biomolecular chemistry More from this journal
- Volume:
- 12
- Issue:
- 11
- Pages:
- 1711-1716
- Publication date:
- 2014-03-01
- DOI:
- EISSN:
-
1477-0539
- ISSN:
-
1477-0520
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:449256
- UUID:
-
uuid:f4fb303a-99ec-43bd-8477-9feaa6c99089
- Local pid:
-
pubs:449256
- Source identifiers:
-
449256
- Deposit date:
-
2014-02-23
Terms of use
- Copyright holder:
- Royal Society of Chemistry
- Copyright date:
- 2014
- Notes:
- This journal is © The Royal Society of Chemistry 2014. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record