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Journal article

Polycomb eviction as a new distant enhancer function.

Abstract:

Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression is still poorly understood. Here, we analyze the influence of a remote enhancer on the balance between repression (Polycomb-PcG) and activation (Trithorax-TrxG) of a developmentally regulated gene associated with a CpG island. We reveal its essential, nonredundant role in clearing the PcG complex and H3K27me3 from the CpG island. In the absence of the enhancer, the...

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Publication status:
Published

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Publisher copy:
10.1101/gad.16985411

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Journal:
Genes and development
Volume:
25
Issue:
15
Pages:
1583-1588
Publication date:
2011-08-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:f4f4aa7a-c761-45f9-b642-ff358623eed8
Source identifiers:
170189
Local pid:
pubs:170189

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