Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men.

Journal article

BACKGROUND: Alimentary lipemia has been associated with coronary heart disease and common carotid artery intima-media thickness (IMT). This study was designed to investigate the relations of subclasses of postprandial triglyceride-rich lipoproteins (TRLs) with IMT. METHODS AND RESULTS: Ninety-six healthy 50-year-old men with an apolipoprotein (apo) E3/E3 genotype underwent an oral fat tolerance test and B-mode carotid ultrasound examination. The apo B-48 and apo B-100 contents of each fraction of TRLs were determined as a measure of chylomicron remnant and VLDL particle concentrations. In the fasting state, LDL cholesterol (P<0.05) and basal proinsulin (P<0. 05) were significantly related to IMT, whereas HDL cholesterol, plasma triglycerides, and insulin were not. In the postprandial state, plasma triglycerides at 1 to 4 hours (P<0.01 at 2 hours), total triglyceride area under the curve (AUC) (P<0.05), incremental triglyceride AUC (P<0.01), and the large VLDL (Sf 60 to 400 apo B-100) concentration at 3 hours (P<0.05) were significantly related to IMT. Multivariate analyses showed that plasma triglycerides at 2 hours, LDL cholesterol, and basal proinsulin were consistently and independently related to IMT when cumulative tobacco consumption, alcohol intake, waist-to-hip circumference ratio, and systolic blood pressure were included as confounders. CONCLUSIONS: These results provide further evidence for postprandial triglyceridemia as an independent risk factor for early atherosclerosis and also suggest that the postprandial triglyceridemia is a better predictor of IMT than particle concentrations of individual TRLs.

Authors: Boquist, S; Ruotolo, G; Tang, R; Björkegren, J; Bond, MG

• Publication status: Published
• Journal: Circulation
• Volume: 100
• Issue: 7
• Pages: 723-728
• Publication date: 1999-08-01
• DOI: 10.1161/01.cir.100.7.723
• EISSN: 1524-4539
• ISSN: 0009-7322
• Language: English
• Keywords: Humans; Alcohol Drinking; Lipoproteins, VLDL; Carotid Stenosis; Middle Aged; Cholesterol, LDL; Blood Pressure; Arteriosclerosis; Sweden; Insulin; Apolipoprotein E3; Body Constitution; Dietary Fats; Apolipoproteins E; Tunica Intima; Smoking; Apolipoproteins B; Fasting; Triglycerides; Area Under Curve; Proinsulin; Chylomicrons; Reference Values; Male; Genotype; Homeostasis; Apolipoprotein B-48; Apolipoprotein B-100; Lipids; Lipoproteins; Eating; Carotid Artery, Common