Bioinformatic strategies for unambiguous identification of prostate specific antigen in clinical samples.

Journal article

Prostate specific antigen (PSA), as a widely used clinical biomarker in prostate cancer diagnostics, exists in multiple molecular forms. However, all of these forms might not be recognized in a given sample by the standard immunoassays. Therefore, we have investigated PSA isoforms, separated by size, using mass spectrometric analyses. The objective of these developments was to identify and specify the various forms of PSA. To optimize successful identification of different PSA forms, we have ...

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Authors: Végvári, A; Rezeli, M; Häkkinen, J; Sihlbom, C; Carlsohn, E

• Journal: Journal of proteomics
• Volume: 75
• Issue: 1
• Pages: 202-210
• Publication date: 2011-12-01
• DOI: 10.1016/j.jprot.2011.06.008
• EISSN: 1876-7737
• ISSN: 1874-3919
• Language: English
• Keywords: Software; Prostate-Specific Antigen; Prostatic Neoplasms; Male; Computational Biology; Humans; Protein Isoforms; Amino Acid Sequence; Trypsin; Molecular Sequence Data; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Peptide Fragments