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Cytotoxic T lymphocytes form an antigen-independent ring junction

Abstract:

Immunological synapses are organized cell-cell junctions between T lymphocytes and APCs composed of an adhesion ring, the peripheral supramolecular activation cluster (pSMAC), and a central T cell receptor cluster, the central supramolecular activation cluster (cSMAC). In CD8 + cytotoxic T lymphocytes, the immunological synapse is thought to facilitate specific killing by confining cytotoxic agents to the synaptic cleft. We have investigated the interaction of human CTLs and helper T cells wi...

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Publisher copy:
10.1172/JCI200419337

Authors


Somersalo, K More by this author
Anikeeva, N More by this author
Thomas, VK More by this author
Strong, RK More by this author
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Journal:
Journal of Clinical Investigation
Volume:
113
Issue:
1
Pages:
49-57
Publication date:
2004-01-05
DOI:
ISSN:
0021-9738
URN:
uuid:f4e48aaf-8f46-4925-ba53-18953d3b6b7d
Source identifiers:
482731
Local pid:
pubs:482731
Language:
English

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