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Common genetic variation and the control of HIV-1 in humans.

Abstract:

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibil...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1000791

Authors


Shianna, KV More by this author
Colombo, S More by this author
Ledergerber, B More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
5
Issue:
12
Pages:
e1000791
Publication date:
2009-12-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:f4e276a4-7719-4bc0-a8b4-c77b1657dc57
Source identifiers:
46204
Local pid:
pubs:46204

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