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Occasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosis

Abstract:

The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower motor neuron (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected by electromyography (EMG),3 but, as yet, there are no generally accepted markers for monitoring UMN abnormalities,4 the neurobiology of ALS itself and disease spread through the brain and the spinal cord.5 Full clinical assessment i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Role:
Author
ORCID:
0000-0002-8717-8914
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-0267-3180
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Name:
Motor Neurone Disease Association
Grant:
TURNER/OCT18/989-797
Publisher:
BMJ Publishing Group
Journal:
Journal of Neurology, Neurosurgery, and Psychiatry More from this journal
Volume:
91
Issue:
3
Pages:
227-234
Place of publication:
England
Publication date:
2020-02-13
Acceptance date:
2019-10-24
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pmid:
32054724
Language:
English
Keywords:
Pubs id:
1089137
Local pid:
pubs:1089137
Deposit date:
2020-03-23

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