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G6PD Deficiency. Global Distribution, Genetic Variants and Primaquine Therapy

Abstract:

Glucose-6-phosphate dehydrogenase (G6PD) is a potentially pathogenic inherited enzyme abnormality and, similar to other human red blood cell polymorphisms, is particularly prevalent in historically malaria endemic countries. The spatial extent of Plasmodium vivax malaria overlaps widely with that of G6PD deficiency; unfortunately the only drug licensed for the radical cure and relapse prevention of P. vivax, primaquine, can trigger severe haemolytic anaemia in G6PD deficient individuals. This...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Advances in Parasitology More from this journal
Volume:
81
Pages:
135-201
Publication date:
2013-01-01
DOI:
ISSN:
0065-308X
Language:
English
Keywords:
Pubs id:
pubs:384725
UUID:
uuid:f4d3ff10-44fb-4cf6-b9e3-5235570c269f
Local pid:
pubs:384725
Source identifiers:
384725
Deposit date:
2013-11-16

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