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Journal article

MRI in Leber's hereditary optic neuropathy: the relationship to multiple sclerosis.

Abstract:

BACKGROUND: Leber's hereditary optic neuropathy (LHON) and a multiple sclerosis (MS)-like illness appear to coexist 50 times more frequently than would be expected by chance. This association of LHON and MS (LMS) raises an important question about whether there could be a common pathophysiological mechanism involving mitochondrial dysfunction. OBJECTIVE: The primary aim was to define MRI features of LMS and LHON, and to assess the proportions of individuals displaying features typical of MS. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/jnnp-2014-308186

Authors


Matthews, L More by this author
Enzinger, C More by this author
Fazekas, F More by this author
Ciccarelli, O More by this author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Neurology, Neurosurgery and Psychiatry Journal website
Volume:
86
Pages:
537-542
Publication date:
2014-07-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:f4b5c4ea-2433-4f5d-9205-4a34ffb06d3d
Source identifiers:
476987
Local pid:
pubs:476987
Language:
English
Keywords:

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