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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Abstract:

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate cau...

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Publication status:
Published

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Publisher copy:
10.1038/ng.287

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Journal:
Nature genetics More from this journal
Volume:
41
Issue:
1
Pages:
25-34
Publication date:
2009-01-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036

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