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Journal article

DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion

Abstract:

Neural crest cells are both highly migratory and significant to vertebrate organogenesis. However, the signals that regulate neural crest cell migration remain unclear. Here, we test the function of DAN, a BMP antagonist we detected by analysis of chick cranial mesoderm. Our analysis shows that, prior to neural crest cell exit from the hindbrain, DAN is expressed in the mesoderm, then it becomes absent along cell migratory pathways. Cranial neural crest and metastatic melanoma cells avoid DAN...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1083/jcb.201612169

Authors


McLennan, R More by this author
Schumacher, LJ More by this author
Morrison, J More by this author
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Funding agency for:
Baker, R
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
216
Issue:
10
Pages:
3339-3354
Publication date:
2017-08-15
Acceptance date:
2017-07-12
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pubs id:
pubs:709120
URN:
uri:f4aec651-89db-4ea9-b93c-0adbe5ffb6ee
UUID:
uuid:f4aec651-89db-4ea9-b93c-0adbe5ffb6ee
Local pid:
pubs:709120

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