A first update on mapping the human genetic architecture of COVID-19

Journal article

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.Here we present meta-analyses bringing together 60 studies from 25 countries for three COVID-19-related phenotypes: [...

Authors: Nguyen, H; Solomonson, M; Palotie, A; Davis, L; Lee, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature
• Volume: 608
• Issue: 7921
• Pages: E1-E10
• Publication date: 2022-08-03
• DOI: 10.1038/s41586-022-04826-7
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Disease; Biology; Coronavirus disease 2019 (COVID-19); Outbreak; Infectious disease (medical specialty); Computer science; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; 2019-20 coronavirus outbreak; Architecture; Computational biology; Evolutionary biology; Geography; Medicine