Journal article
TLR adaptor protein MYD88 mediates sensitivity to HDAC inhibitors via a cytokine-dependent mechanism
- Abstract:
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Histone deacetylase (HDAC) inhibitors have proven useful therapeutic agents for certain haematological cancers. However, HDAC inhibition causes diverse cellular outcomes, and identification of cancer-relevant pathways within these outcomes remains unresolved. In this study, we utilized an unbiased loss-of-function screen and identified the Toll-like receptor (TLR) adaptor protein MYD88 as a key regulator of the anti-proliferative effects of HDAC inhibition. High expression of MYD88 exhibited ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 9.4MB)
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(Accepted manuscript, pdf, 7.7MB)
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(Accepted manuscript, pdf, 923.2KB)
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(Accepted manuscript, pdf, 470.9KB)
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- Publisher copy:
- 10.1158/0008-5472.CAN-16-0504
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Authors
Funding
Medical Research Council
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Rosetrees Trust
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Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Research Journal website
- Volume:
- 76
- Issue:
- 23
- Pages:
- 6975-6987
- Publication date:
- 2016-10-12
- Acceptance date:
- 2016-09-20
- DOI:
- EISSN:
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1538-7445
- ISSN:
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0008-5472
- Source identifiers:
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653010
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:653010
- UUID:
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uuid:f4ab53c1-24ed-44ce-aff5-b3f2c5e4fe2e
- Local pid:
- pubs:653010
- Deposit date:
- 2016-11-05
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2016
- Notes:
- Copyright © 2016, American Association for Cancer Research. This is the accepted manuscript version of the article. The final version is available online from the American Association for Cancer Research at: https://doi.org/10.1158/0008-5472.CAN-16-0504
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