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TLR adaptor protein MYD88 mediates sensitivity to HDAC inhibitors via a cytokine-dependent mechanism

Abstract:

Histone deacetylase (HDAC) inhibitors have proven useful therapeutic agents for certain haematological cancers. However, HDAC inhibition causes diverse cellular outcomes, and identification of cancer-relevant pathways within these outcomes remains unresolved. In this study, we utilized an unbiased loss-of-function screen and identified the Toll-like receptor (TLR) adaptor protein MYD88 as a key regulator of the anti-proliferative effects of HDAC inhibition. High expression of MYD88 exhibited ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1158/0008-5472.CAN-16-0504

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Department:
Oxford, MSD, Oncology
Role:
Author
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Department:
Oxford, MSD, Oncology
Role:
Author
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Department:
Oxford, MSD, Oncology
Role:
Author
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Department:
Oxford, MSD, NDM, Target Discovery Institute
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Author
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Medical Research Council More from this funder
Rosetrees Trust More from this funder
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
76
Issue:
23
Pages:
6975-6987
Publication date:
2016-10-12
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Pubs id:
pubs:653010
URN:
uri:f4ab53c1-24ed-44ce-aff5-b3f2c5e4fe2e
UUID:
uuid:f4ab53c1-24ed-44ce-aff5-b3f2c5e4fe2e
Local pid:
pubs:653010
Paper number:
23
Language:
English
Keywords:

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