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Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein.

Abstract:

OBJECTIVE: Baseline concentrations of plasma C-reactive protein (CRP) are associated with coronary heart disease. Interleukin-6 (IL-6) regulates CRP gene expression; a promoter polymorphism (-174G/C) of the IL-6 gene has been shown to influence IL-6 transcription but the relationship between genotype at this polymorphism and circulating levels of inflammatory markers remains unclear. We hypothesised that plasma CRP would be a heritable phenotype that would be influenced by genotype at this p...

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Publication status:
Published

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Journal:
Cardiovascular research
Volume:
53
Issue:
4
Pages:
1029-1034
Publication date:
2002-03-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:f49e9a83-01b2-4d6e-b690-9fd1457d0628
Source identifiers:
9082
Local pid:
pubs:9082

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