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Localization of the Tamm-Horsfall glycoprotein (uromodulin) gene to chromosome 16p12.3-16p13.11.

Abstract:
Mapping studies using a panel of 22 rodent-human somatic cell hybrids have helped to localize the Tamm-Horsfall glycoprotein (uromodulin) gene (UMOD), which has previously been reported to map to 16p13.11, to the region 16p12.3-qter. The combined results indicate that UMOD is located distal to D16S295 and proximal to D16S287 and in the region 16p12.3-16p13.11. Uromodulin is known to affect the formation of calcium-containing kidney stones, and this localization of UMOD will help in studies of families with autosomal forms of nephrolithiasis.
Publication status:
Published

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Authors


Jeremiah, S More by this author
Scheinman, SJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Annals of human genetics
Volume:
57
Issue:
Pt 4
Pages:
285-290
Publication date:
1993-10-05
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
URN:
uuid:f49b2fa7-176e-4169-abc5-580f001cba5f
Source identifiers:
19282
Local pid:
pubs:19282

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