Localization of the Tamm-Horsfall glycoprotein (uromodulin) gene to chromosome 16p12.3-16p13.11.

Journal article

Mapping studies using a panel of 22 rodent-human somatic cell hybrids have helped to localize the Tamm-Horsfall glycoprotein (uromodulin) gene (UMOD), which has previously been reported to map to 16p13.11, to the region 16p12.3-qter. The combined results indicate that UMOD is located distal to D16S295 and proximal to D16S287 and in the region 16p12.3-16p13.11. Uromodulin is known to affect the formation of calcium-containing kidney stones, and this localization of UMOD will help in studies of families with autosomal forms of nephrolithiasis.

Authors: Pook, M; Jeremiah, S; Scheinman, S; Povey, S; Thakker, R

• Publication status: Published
• Journal: Annals of human genetics
• Volume: 57
• Issue: Pt 4
• Pages: 285-290
• Publication date: 1993-10-01
• DOI: 10.1111/j.1469-1809.1993.tb00902.x
• EISSN: 1469-1809
• ISSN: 0003-4800
• Language: English
• Keywords: Chromosomes, Human, Pair 16; Base Sequence; Mucoproteins; Humans; Uromodulin; Osteopontin; Hybrid Cells; Proteins; Kidney Calculi; Animals; Molecular Sequence Data; Rodentia; Chromosome Mapping