Potassium channels: watching a voltage-sensor tilt and twist.

Journal article

The fourth transmembrane helix (S4) is the primary voltage-sensor of voltage-gated ion channels. Recent studies have used fluorescence resonance energy transfer as a spectroscopic ruler to determine the nature and magnitude of the voltage-induced movement of S4 that leads to channel opening.

Authors: Sansom, MS

• Publication status: Published
• Journal: Current biology : CB
• Volume: 10
• Issue: 5
• Pages: R206-R209
• Publication date: 2000-03-01
• DOI: 10.1016/s0960-9822(00)00354-7
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Potassium Channels; Models, Biological; Ion Channel Gating; Models, Molecular; Protein Conformation; Fluorescence; Energy Transfer; Magnetic Resonance Spectroscopy