Ca2+ and synaptic plasticity.

Journal article

The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell. The Ca2+ signals within these compartments are generated by voltage or ligand-gated Ca2+ influx, and release from intracellular stores. The changes in [Ca2+]i are directly linked to the activity of the neurone, thus a neurone's input and output is translated into a dynamic Ca2+ code. Despite considerable progress in measuring this code much still remains to be determined in order to understand how the code is interpreted by the Ca2+ sensors that underlie the induction of compartment-specific plastic changes.

Authors: Cavazzini, M; Bliss, T; Emptage, N

• Publication status: Published
• Journal: Cell calcium
• Volume: 38
• Issue: 3-4
• Pages: 355-367
• Publication date: 2005-01-01
• DOI: 10.1016/j.ceca.2005.06.013
• EISSN: 1532-1991
• ISSN: 0143-4160
• Language: English
• Keywords: Calcium; Animals; Long-Term Synaptic Depression; Calcium Signaling; Humans; Dendritic Spines; Neuronal Plasticity; Long-Term Potentiation; Synapses