Epstein-Barr Virus associated gastric carcinoma

Journal article

Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus associated with a variety of human malignancies including lymphoma and so-called lymphoepithelial carcinoma seen in a variety of sites, including the stomach. EBV has been detected in 5-20% of gastric carcinomas worldwide. Evidence is presented which suggests that failure of EBV-specific immunity may play a role in the pathogenesis of EBV-associated malignancy. In this paper, we review the clinicopathologic features, molecular pathology, immunologic aspect, environmental factors in EBV-associated gastric carcinoma and lastly, EBV-targeted therapy.

Authors: Oh, H; Chetty, R

• Publication status: Published
• Journal: GENE THERAPY AND MOLECULAR BIOLOGY
• Volume: 11A
• Issue: 1
• Pages: 51-59
• Publication date: 2007-01-01
• ISSN: 1529-9120
• Language: English
• Keywords: gastric carcinoma; Epstein-Barr virus; EBV-targeted therapy; environmental factors; clinicopathologic features; immunology; molecular pathology