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Pooled sequencing and rare variant association tests for identifying the determinants of emerging drug resistance in malaria parasites.

Abstract:

We explored the potential of pooled sequencing to swiftly and economically identify selective sweeps due to emerging artemisinin (ART) resistance in a South-East Asian malaria parasite population. ART resistance is defined by slow parasite clearance from the blood of ART-treated patients and mutations in the kelch gene (chr. 13) have been strongly implicated to play a role. We constructed triplicate pools of 70 slow-clearing (resistant) and 70 fast-clearing (sensitive) infections collected fr...

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Publisher copy:
10.1093/molbev/msu397

Authors


Cheeseman, IH More by this author
McDew-White, M More by this author
Sriprawat, K More by this author
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Journal:
Mol Biol Evol
Publication date:
2014-12-21
DOI:
EISSN:
1537-1719
URN:
uuid:f48a3fde-bbce-4ea8-a2a5-9b108c1d0513
Source identifiers:
502290
Local pid:
pubs:502290
Language:
English

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