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Manganese accumulation in pancreatic beta-cells and its stimulation by glucose.

Abstract:

Electrothermal atomic-absorption spectroscopy was employed for measuring manganese in beta-cell-rich pancreatic islets microdissected from ob/ob mice. The islet content of endogenous manganese was 80 mumol/kg dry wt., which is about half as much as found in the exocrine pancreas. The initial uptake was characterized by two components, with approximate Km values of 35 microM and 3.7 microM respectively. After 60 min of incubation with 0.25 mM-Mn2+, the intracellular concentration of manganese ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Biochemical journal
Volume:
202
Issue:
2
Pages:
435-444
Publication date:
1982-02-01
EISSN:
1470-8728
ISSN:
0264-6021
Source identifiers:
6178
Language:
English
Keywords:
Pubs id:
pubs:6178
UUID:
uuid:f48a0d91-d1c8-4849-a1c1-e5bd4f1c9f56
Local pid:
pubs:6178
Deposit date:
2012-12-19

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