Glycomics investigation into insulin action.

Journal article

Defects in glycosylation are becoming increasingly associated with a range of human diseases. In some cases, the disease is caused by the glycosylation defect, whereas in others, the aberrant glycosylation may be a consequence of the disease. The implementation of highly sensitive and rapid mass spectrometric screening strategies for profiling the glycans present in model biological systems is revealing valuable insights into disease phenotypes. In addition, glycan screening is proving useful...

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Authors: Parry, S; Hadaschik, D; Blancher, C; Kumaran, M; Bochkina, N

• Publication status: Published
• Journal: Biochimica et biophysica acta
• Volume: 1760
• Issue: 4
• Pages: 652-668
• Publication date: 2006-04-01
• DOI: 10.1016/j.bbagen.2005.12.013
• ISSN: 0006-3002
• Language: English
• Keywords: Muscles; Insulin; Liver; Glycoproteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; 3T3-L1 Cells; Insulin Resistance; Mice, Inbred Strains; Transcription, Genetic; Polysaccharides; Animals; Glycosylation; Gene Expression Regulation; Gene Expression Profiling; Mice