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Journal article

The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguity.

Abstract:

Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluR-A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild-type and sham-operated controls, respectively, on a conditional learning task using an elevated T-maze. Floor inserts (white perspex vs wire mesh) provided a conditional cue indicating in which goal arm a food reward was to be found. The relationship between the floor insert and the rewarded goal arm was constant throughout the experim...

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Publication status:
Published

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Authors


Schmitt, WB More by this author
Arianpour, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Seeburg, PH More by this author
Sprengel, R More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
24
Issue:
33
Pages:
7277-7282
Publication date:
2004-08-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:f4817209-25d2-4314-9727-2a429ee69628
Source identifiers:
15337
Local pid:
pubs:15337

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