Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis.

Journal article

OBJECTIVE: Antibodies to glutamic acid decarboxylase (GAD) have been described in a few patients with temporal lobe epilepsies consistent with limbic encephalitis (LE). We studied a cohort of patients with recent-onset temporal lobe epilepsy caused by LE to test for GAD antibody positivity and response to immunotherapies. METHODS: Over a period of 3.75 years, 138 patients aged >or=18 years investigated at the Department of Epileptology, University of Bonn, for recent-onset epilepsy were p...

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Authors: Malter, M; Helmstaedter, C; Urbach, H; Vincent, A; Bien, C

• Publication status: Published
• Journal: Annals of neurology
• Volume: 67
• Issue: 4
• Pages: 470-478
• Publication date: 2010-04-01
• DOI: 10.1002/ana.21917
• EISSN: 1531-8249
• ISSN: 0364-5134
• Language: English
• Keywords: Glutamate Decarboxylase; Immunoglobulins, Intravenous; Prospective Studies; Middle Aged; Young Adult; Aged; Aged, 80 and over; Adult; Positron-Emission Tomography; Male; Potassium Channels, Voltage-Gated; Fluorodeoxyglucose F18; Female; Neuropsychological Tests; Antibodies; Treatment Outcome; Magnetic Resonance Imaging; Follow-Up Studies; Statistics, Nonparametric; Adolescent; Humans; Limbic Encephalitis; Retrospective Studies