Journal article
Nanoscale biodegradable printing for designed tuneability of vaccine delivery kinetics
- Abstract:
- Two-photon polymerization (2PP) 3D printing enables top-down biomaterial synthesis with nanoscale spatial resolution for de novo design of monodisperse injectable drug delivery systems. Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel poly(lactic-co-glycolic acid)-triacrylate resin family with sub-micron resolution and tuneable hydrolysis that addresses the limitations of current 2PP resins. SCRIBE enables the direct printing of hollow microparticles with tuneable chemistry and complex geometries inaccessible to molding techniques, which are used to engineer controlled protein release in vitro and in vivo. SCRIBE microparticles are used to modulate antibody titers and class switching as a function of antigen release rate and extend these findings to enable a single-injection vaccine formulation with extended antibody induction kinetics. Demonstrating how the chemistry and computer-aided design of 2PP-printed microparticles can be used to tune responses to biomacromolecule release in vivo opens significant opportunities for a new generation of drug delivery vehicles.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 10.7MB, Terms of use)
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(Preview, Supplementary materials, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1002/adma.202417290
Authors
+ Marie Curie
More from this funder
- Funder identifier:
- https://ror.org/02aqv1x10
- Grant:
- 101027174
- 890854
- 893158
- 839137
+ Gates Foundation
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- Funder identifier:
- https://ror.org/0456r8d26
- Grant:
- INV-003863
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/R015651/1
+ Royal Academy of Engineering
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- Funder identifier:
- https://ror.org/0526snb40
- Grant:
- CiET2021\94
- Publisher:
- Wiley
- Journal:
- Advanced Materials More from this journal
- Volume:
- 37
- Issue:
- 15
- Article number:
- 2417290
- Place of publication:
- Germany
- Publication date:
- 2025-02-28
- Acceptance date:
- 2025-02-11
- DOI:
- EISSN:
-
1521-4095
- ISSN:
-
0935-9648
- Pmid:
-
40018867
- Language:
-
English
- Keywords:
- Pubs id:
-
2092953
- Local pid:
-
pubs:2092953
- Deposit date:
-
2025-04-24
- ARK identifier:
Terms of use
- Copyright holder:
- Peeler et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Author(s). Advanced Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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