Control of intestinal inflammation by regulatory T cells.

Journal article

Transfer of CD4+ T cells to immune-deficient mice in the absence of the CD25+ subset leads to the development of colitis, indicating that regulatory cells capable of controlling a bacteria-driven inflammatory response are present in normal mice. Cells with this function are present in the thymus as well as in the periphery of germ-free mice, suggesting they may be reactive with self-antigen. These cells resemble CD4+CD25+ cells that inhibit organ-specific autoimmunity, suggesting that a simil...

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Authors: Singh, B; Read, S; Asseman, C; Malmström, V; Mottet, C

• Publication status: Published
• Journal: Immunological reviews
• Volume: 182
• Issue: 1
• Pages: 190-200
• Publication date: 2001-08-01
• DOI: 10.1034/j.1600-065x.2001.1820115.x
• EISSN: 1600-065X
• ISSN: 0105-2896
• Language: English
• Keywords: T-Lymphocyte Subsets; Dendritic Cells; Antigens, Differentiation; Humans; Membrane Glycoproteins; Transforming Growth Factor beta; Animals; Bacteria; Thymus Gland; Antigens, CD; Antigens, CD45; NAD+ Nucleosidase; Colitis; ADP-ribosyl Cyclase; Inflammatory Bowel Diseases; Antigens, CD38; Interleukin-10; Receptors, Interleukin-2