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Journal article

Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors.

Abstract:

The ability to deliver a large transgene efficiently to photoreceptors using viral vectors remains problematic and yet is critical for the future therapy of inherited retinal diseases such as Stargardt's and Usher's 1B. Herein, we examine the ocular tropism of a HIV-1-based lentivirus vector pseudotyped with Venezuelan equine encephalitis virus-derived glycoprotein (VEEV-G) after intraocular delivery to the posterior and anterior chambers of C57BL/6 wild-type mice. Reporter gene (EGFP) expres...

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Publication status:
Published

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Publisher copy:
10.1089/hum.2013.009

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Journal:
Human gene therapy
Volume:
25
Issue:
1
Pages:
50-62
Publication date:
2014-01-05
DOI:
EISSN:
1557-7422
ISSN:
1043-0342
URN:
uuid:f46afb4d-24cd-413a-9a37-c4ff8547a39d
Source identifiers:
434258
Local pid:
pubs:434258

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