Journal article
Universal dynamic fitting of magnetic resonance spectroscopy
- Abstract:
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Purpose: Dynamic (2D) magnetic resonance spectroscopy is a collection of techniques where acquisitions of spectra are repeated under varying experimental or physiological conditions. Dynamic MRS comprises a rich set of contrasts, including diffusion-weighted, relaxation-weighted, functional, edited, or hyperpolarized spectroscopy, leading to quantitative insights into multiple physiological or microstructural processes. Conventional approaches to dynamic MRS analysis ignore the shared information between spectra, and instead proceed by independently fitting noisy individual spectra before modelling temporal changes in the parameters. Here we propose a universal dynamic MRS toolbox which allows simultaneous fitting of dynamic spectra of arbitrary type.
Methods: A simple user-interface allows information to be shared and precisely modelled across spectra to make inferences on both spectral and dynamic processes. We demonstrate and thoroughly evaluate our approach in three types of dynamic MRS techniques. Simulations of functional and edited MRS are used to demonstrate the advantages of dynamic fitting.
Results: Analysis of synthetic functional 1H-MRS data shows a marked decrease in parameter uncertainty as predicted by prior work. Analysis with our tool replicates the results of two previously published studies using the original in vivo functional and diffusion-weighted data. Finally, joint spectral fitting with diffusion orientation models is demonstrated in synthetic data.
Conclusion: A toolbox for generalised and universal fitting of dynamic, interrelated MR spectra has been released and validated. The toolbox is shared as a fully open-source software with comprehensive documentation, example data, and tutorials.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 4.4MB, Terms of use)
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- Publisher copy:
- 10.1002/mrm.30001
Authors
- Grant:
- 225924/Z/22/Z
- 203139/A/16/Z
- 203139/Z/16/Z
- 215573/Z/19/Z
- 221933/Z/20/Z
- Publisher:
- Wiley
- Journal:
- Magnetic Resonance in Medicine More from this journal
- Volume:
- 91
- Issue:
- 6
- Pages:
- 2229-2246
- Publication date:
- 2024-01-24
- Acceptance date:
- 2023-12-18
- DOI:
- EISSN:
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1522-2594
- ISSN:
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0740-3194
- Language:
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English
- Keywords:
- Pubs id:
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1585379
- Local pid:
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pubs:1585379
- Deposit date:
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2023-12-18
Terms of use
- Copyright holder:
- Clarke et al
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Notes:
- For the purposes of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Accepted Author Manuscript version arising from this submission.
- Licence:
- CC Attribution (CC BY)
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