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USE OF THIAZOLIDINEDIONES AND RISK OF OSTEOPOROTIC FRACTURE: DISEASE OR DRUGS?

Abstract:

Purpose: Clinical and observational studies suggest that use of thiazolidinediones (TZDs) is associated with an increased fracture risk. In addition, type 2 diabetes mellitus (T2DM) is a risk factor for osteoporotic fracture. Our aim was to estimate fracture risks in TZD users and users of other antidiabetic drugs, classified according to proxies of disease severity. Methods: We conducted a population-based cohort study utilizing the Dutch PHARMO database (1998-2008). PHARMO links pharmacy-di...

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Publication status:
Published

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Publisher copy:
10.1002/pds.3234

Authors


Bazelier, M More by this author
van Staa, T More by this author
Leufkens, H More by this author
Vestergaard, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Volume:
21
Issue:
5
Pages:
S451-S451
Publication date:
2010-11-05
DOI:
EISSN:
1099-1557
ISSN:
0937-941X
URN:
uuid:f454e9d0-69af-4ddc-9c2b-aac1881e4247
Source identifiers:
146522
Local pid:
pubs:146522

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