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Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery

Abstract:

Background: New vaccines to prevent tuberculosis are urgently needed. MVA85A is a novel viral vector TB vaccine candidate designed to boost BCG-induced immunity when delivered intradermally. To date, intramuscular delivery has not been evaluated. Skin and muscle have distinct anatomical and immunological properties which could impact upon vaccine-mediated cellular immunity. Methods: We conducted a randomised phase I trial comparing the safety and immunogenicity of 1×108pfu MVA85A delivered in...

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Journal:
Vaccine
Volume:
31
Issue:
7
Pages:
1026-1033
Publication date:
2013-02-04
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:f44efa7d-1504-4e31-aae5-234ed8cc0450
Source identifiers:
379459
Local pid:
pubs:379459
Language:
English
Keywords:

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