- Abstract:
-
Background: New vaccines to prevent tuberculosis are urgently needed. MVA85A is a novel viral vector TB vaccine candidate designed to boost BCG-induced immunity when delivered intradermally. To date, intramuscular delivery has not been evaluated. Skin and muscle have distinct anatomical and immunological properties which could impact upon vaccine-mediated cellular immunity. Methods: We conducted a randomised phase I trial comparing the safety and immunogenicity of 1×108pfu MVA85A delivered in...
Expand abstract - Publisher copy:
- 10.1016/j.vaccine.2012.12.042
-
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- Journal:
- Vaccine
- Volume:
- 31
- Issue:
- 7
- Pages:
- 1026-1033
- Publication date:
- 2013-02-04
- DOI:
- EISSN:
-
1873-2518
- ISSN:
-
0264-410X
- URN:
-
uuid:f44efa7d-1504-4e31-aae5-234ed8cc0450
- Source identifiers:
-
379459
- Local pid:
- pubs:379459
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery
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