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A role for chromatin remodeling in transcriptional termination by RNA polymerase II.

Abstract:

Chromatin remodeling can facilitate the recruitment of RNA polymerase II (Pol II) to targeted promoters, as well as enhancing the level of transcription. Here, we describe a further key role for chromatin remodeling in transcriptional termination. Using a genetic screen in S. pombe, we identified the CHD-Mi2 class chromatin remodeling ATPase, Hrp1, as a termination factor. In S. cerevisiae, we show that transcriptional termination and chromatin structure at the 3' ends of three genes all depe...

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Publication status:
Published

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Journal:
Molecular cell More from this journal
Volume:
10
Issue:
6
Pages:
1441-1452
Publication date:
2002-12-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Language:
English
Keywords:
Pubs id:
pubs:25784
UUID:
uuid:f4457008-b28b-4c04-afd9-5360f3386e98
Local pid:
pubs:25784
Source identifiers:
25784
Deposit date:
2012-12-19

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