Journal article icon

Journal article

Impact of efavirenz, ritonavir-boosted lopinavir and nevirapine based antiretroviral regimens on the pharmacokinetics of lumefantrine and safety of artemether-lumefantrine in falciparum-negative HIV-infected Malawian adults stabilized on antiretroviral therapy

Abstract:

There is conflicting evidence of the impact of commonly used antiretroviral therapies (ARTs) on the pharmacokinetics of lumefantrine and safety profile of artemether-lumefantrine. We compared the area under the concentration-time curve (AUC0-14 days) of lumefantrine and safety profile of artemether-lumefantrine in malaria-negative human immunodeficiency virus (HIV) infected adults in two steps. In step 1, a half-dose adult course of artemether-lumefantrine was administered as a safety check i...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1128/aac.01162-18

Authors


Dzinjalamala, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Mallewa, J More by this author
Expand authors...
European and Developing Countries Clinical Trials Partnership More from this funder
World Health Organization More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
11
Pages:
e01162-18
Publication date:
2018-08-27
Acceptance date:
2018-08-11
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:912194
URN:
uri:f4443c3d-26c2-4d71-82a0-74c72c8cfe01
UUID:
uuid:f4443c3d-26c2-4d71-82a0-74c72c8cfe01
Local pid:
pubs:912194

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP