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The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.

Abstract:

The complete nucleotide sequence of a human alpha-globin pseudogene (psi alpha 1) is presented. Comparison of this sequence with a normal human alpha-globin gene (alpha 2) reveals that psi alpha 1 contains both an initiator codon mutation and frameshift deletions which would prevent the production of an alpha-globin polypeptide. psi alpha 1 contains two intervening sequences with sizes and locations characteristic of mammalian alpha-globin genes. However, the alteration or absence of putative...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cell More from this journal
Volume:
21
Issue:
2
Pages:
537-544
Publication date:
1980-09-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
pubs:28943
UUID:
uuid:f43c8fe8-6038-4783-b746-751a1ba1ebb3
Local pid:
pubs:28943
Source identifiers:
28943
Deposit date:
2012-12-19

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