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Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.

Abstract:

Glucose stimulates insulin secretion from the pancreatic beta-cell by increasing the cytosolic calcium concentration. It is believed that this increment results mainly from Ca2+ influx through dihydropyridine-sensitive calcium channels because insulin secretion is abolished by dihydropyridine antagonists and is potentiated by dihydropyridine agonists. Glucose may influence Ca2+ influx through these channels in two ways: either by regulating the beta-cell membrane potential or by biochemical m...

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Publication status:
Published

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Publisher copy:
10.1038/342550a0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Nature
Volume:
342
Issue:
6249
Pages:
550-553
Publication date:
1989-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:f43b569d-c779-42a5-86ee-5c59615f4e57
Source identifiers:
4694
Local pid:
pubs:4694

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