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Population pharmacokinetics of intramuscular artesunate in African children with severe malaria: implications for a practical dosing regimen.

Abstract:

Parenteral artesunate (ARS) is the drug of choice for the treatment of severe malaria. Pharmacokinetics data on intramuscular ARS are limited with respect to the main treatment group that carries the highest mortality, namely, critically ill children with severe malaria. A population pharmacokinetic study of ARS and dihydroartemisinin (DHA) was conducted from sparse sampling in 70 Tanzanian children of ages 6 months to 11 years. All the children had been admitted with severe falciparum malari...

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Publication status:
Published

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Publisher copy:
10.1038/clpt.2013.26

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Journal:
Clinical pharmacology and therapeutics More from this journal
Volume:
93
Issue:
5
Pages:
443-450
Publication date:
2013-05-01
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
Language:
English
Keywords:
Pubs id:
pubs:390794
UUID:
uuid:f43af4da-3c5d-4e73-b664-4d389490b7a5
Local pid:
pubs:390794
Source identifiers:
390794
Deposit date:
2013-11-17

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