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IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2.

Abstract:

Resistance or susceptibility to most infectious diseases is strongly determined by the balance of type 1 vs type 2 cytokines produced during infection. However, for viruses, this scheme may be applicable only to infections with some cytopathic viruses, where IFN-gamma is considered as mandatory for host defense with little if any participation of type 2 responses. We studied the role of signature Th1 (IL-12, IFN-gamma) and Th2 (IL-4, IL-10) cytokines for immune responses against vaccinia viru...

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Publication status:
Published

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Authors


van Den Broek, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Köhler, G More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
164
Issue:
1
Pages:
371-378
Publication date:
2000-01-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:f43a4114-c176-43c1-967a-71b4b1c4bc9b
Source identifiers:
469268
Local pid:
pubs:469268

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