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Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials

Abstract:

Background Moderate differences in efficacy between adjuvant chemotherapy regimens for breast cancer are plausible, and could affect treatment choices. We sought any such differences.

Methods We undertook individual-patient-data meta-analyses of the randomised trials comparing: any taxane-plus-anthracycline-based regimen versus the same, or more, non-taxane chemotherapy (n=44 000); one anthracycline-based regimen versus another (n=7000) or versus c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Contributor
More from this funder
Name:
British Heart Foundation
Funding agency for:
Cutter, D
Grant:
RE/08/04
Publisher:
Elsevier
Journal:
Lancet More from this journal
Volume:
379
Issue:
9814
Pages:
432-444
Publication date:
2011-12-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Language:
English
Pubs id:
pubs:265059
UUID:
uuid:f4383b86-29a0-4248-9594-085ff8308812
Local pid:
pubs:265059
Source identifiers:
265059
Deposit date:
2012-12-19

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